Neural Crest Migration in Axolotls: white Mutants
We can use a classic axolotl mutant, the white mutant,
to study the role of the extracellular environment in migration
of neural crest that migrate over the dorsal surface of the somite
and underneath the epidermis. You will recall that these neural
crest cells generate pigmented cells that invade the epidermis.
In white mutants, these cells fail to migrate, and remain near
the neural tube after they are produced during neurulation. We
can use this mutation to perform transplantation experiments to
address the cues neural crest cells require inorder to migrate.