Morphogenesis requires that cells make strong connections with one another. We are studying how two complexes, the cadherin complex and the DLG-1/AJM-1 complex are regulated during morphogenesis.
Elongation involves actomyosin mediated contraction of the epidermal cells, transmitted through cell-cell junctions. Junctional actin networks must remodel during this process. We are studying actin-binding proteins that mediate this "self-healing" response to cell shape change.