Morphogenetic Movements

Gastrulation is complicated! Because of this, it is helpful to break the movements of gastrulation down into their component events wherever possible. In general, sheets of cells can engage in only a limited number of morphogenetic movements. This "morphogenetic repertoire" is helpful to keep in mind when we are presented with what seems to be an incomprehensible change in the shape of the embryo. Through careful observation and experimental manipulation that will be discussed in this section, gastrulation can be analyzed in convenient organisms such as amphibians. On this screen and the next, the various major morphogenetic movements that occur during gastrulation in diverse organisms are schematically represented. Some of these movements are only performed by epithelial cells, while others can be performed by both bona fide epithelial cells and by deeper, non-epithelial cells that nevertheless behave as integrated sheets of cells. The latter are poorly understood, but are common in amphibians as well as in higher vertebrates.

Click on a cell movement below to get a fuller description of what is going on.

Invagination Ingression Involution


During invagination, an epithelial sheet bends inward to form an inpocketing. One way to think of this in three dimensions is to imagine that you are poking a partially deflated beach ball inward with your finger. The resulting bulge or tube is an invagination. If the apical side of the epithelium forms the lumen (central empty space) of the tube, then the movement is termed invagination. If the lumen is formed by basal surfaces, then the movement is termed an evagination.
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During ingression, cells leave an epithellial sheet by transforming from well-behaved epithellial cells into freely migrating mesenchyme cells. To do so, they must presumably alter their cellular architecture, alter their program of motility, and alter their adhesive relationship(s) to the surrounding cells. Neural crest cell are an example of a mesenchymal cell type that emigrates out of an epithelium (do you kno which one?).
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During involution, a tissue sheet rolls inward to form an underlying layer via bulk movement of tissue. One helpful image here is of a tank tread or conveyor belt. As material moves in from the edges of the sheet, material originally at the sites of inward rolling (shown in blue here) is free to move further up underneath the exterior tissue.
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