Neural Crest Migration in Axolotls: white Mutants

We can use a classic axolotl mutant, the white mutant, to study the role of the extracellular environment in migration of neural crest that migrate over the dorsal surface of the somite and underneath the epidermis. You will recall that these neural crest cells generate pigmented cells that invade the epidermis. In white mutants, these cells fail to migrate, and remain near the neural tube after they are produced during neurulation. We can use this mutation to perform transplantation experiments to address the cues neural crest cells require inorder to migrate.