C. elegans and Adhesion: Research or Reviews

Microscopy: Reviews and articles

Sea urchins: Research or Reviews

Older work: Articles

Teaching: Articles

Bold = Hardin lab member
Research articles - C. elegans
Lockwood, C., Lynch, A., and Hardin, J. (2008). Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413 dependent apical focusing. J. Cell Sci. 121: 1477-1487. PubMed

Hardin, J., King, R., Thomas-Virnig, C., and Raich, W.B. (2008). Zygotic loss of ZEN-4/MKLP1 results in disruption of epidermal morphogenesis in the C. elegans embryo. Dev. Dyn. 237:830-6. PubMed

Stevenson, T.O., Mercer, K., Cox, E.A., Szewczyk, N.J., Conley, C.A., Hardin, J.D., and Benian, G.M. (2007). unc-94 encodes a tropomodulin in C. elegans. J. Mol. Biol. 374, 936-50. PubMed

Sheffield, M.S., Loveless, T., Hardin, J., and Pettitt, J. (2007). C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions. Curr. Biol. 17, 1791-1796. PubMed

Batchelder EL, Thomas-Virnig CL, Hardin JD, White JG. (2007). Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo. FEBS Letters 581:4337-41. PubMed

Qadota H, Inoue M, Hikita T, Köppen M, Hardin JD, Amano M, Moerman DG, Kaibuchi K. (2007). Establishment of a tissue-specific RNAi system in C. elegans. Gene 400:166-73. PubMed

Phillips, B. T., Kidd, A. R., 3rd, King, R., Hardin, J. and Kimble, J. (2007). Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 104: 3231-6. PubMed

Lee, J.-Y., Marston, D.J., Halberstadt, A., Walston, T., Hardin, J. and B. Goldstein, B.  (2006). Wnt/Frizzled signaling regulates C. elegans gastrulation through activation of actomyosin contractility. Curr. Biol. 16,1986-97. PubMed

Walston, T., Guo, C., Proenca, R., Wu, M., Herman, M., Hardin, J., and Hedgecock, E. (2006). mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev. Bio. 298, 485-497. PubMed

Walston, T., Tuskey, C., Edgar, L., Hawkins, N., Ellis, G., Bowerman, B., Wood, W., and Hardin, J. (2004). Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev. Cell 7, 831-841. PubMed

Thomas-Virnig, C.L., Simske, J.S., Sims, P.A., and Hardin, J. (2004). The inositol 1, 4, 5-trisphosphate receptor regulates epidermal cell migration in Caenorhabditis elegans. Curr. Biol. 14,1882-7. PubMed

Pettitt, J., Cox, E.A., Broadbent, I.D., Flett, A., and Hardin, J. (2003). The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol 162, 15-22. PubMed

Simske, J.S., Köppen, M., Sims, P., Hodgkin, J., Yonkof, A., and Hardin, J. (2003). The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Nat Cell Biol 5, 619-625. PubMed

Köppen, M., Simske, J.S., Sims, P.A., Firestein, B.L., Hall, D.H., Radice, A.D., Rongo, C., and Hardin, J.D. (2001). Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol 3, 983-991. PubMed

Heid, P.J., Raich, W.B., Smith, R., Mohler, W.A., Simokat, K., Gendreau, S.B., Rothman, J.H., and Hardin, J. (2001). The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans. Dev Biol 236, 165-180. PubMed

Raich, W.B., Agbunag, C., and Hardin, J. (1999). Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming. Curr Biol 9, 1139-1146. PubMed

Williams-Masson, E.M., Heid, P.J., Lavin, C.A., and Hardin, J. (1998). The cellular mechanism of epithelial rearrangement during morphogenesis of the Caenorhabditis elegans dorsal hypodermis. Dev Biol 204, 263-276. PubMed

Raich, W.B., Moran, A.N., Rothman, J.H., and Hardin, J. (1998). Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Mol Biol Cell 9, 2037-2049. PubMed

Mohler, W.A., Simske, J.S., Williams-Masson, E.M., Hardin, J.D., and White, J.G. (1998). Dynamics and ultrastructure of developmental cell fusions in the Caenorhabditis elegans hypodermis. Curr Biol 8, 1087-1090. PubMed

George, S.E., Simokat, K., Hardin, J., and Chisholm, A.D. (1998). The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell 92, 633-643. PubMed

Costa, M., Raich, W., Agbunag, C., Leung, B., Hardin, J., and Priess, J.R. (1998). A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol 141, 297-308. PubMed

Williams-Masson, E.M., Malik, A.N., and Hardin, J. (1997). An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis. Development 124, 2889-2901. PubMed

Draper, B.W., Mello, C.C., Bowerman, B., Hardin, J., and Priess, J.R. (1996). MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell 87, 205-216. PubMed
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Reviews - C. elegans and adhesion
Lynch, A.M. and J. Hardin. (2008). The assembly and maintenance of epithelial junctions in C. elegans. Frontiers Biosci., in press.

Hardin, J. (2008). Preview: To thine own self be true: Self-fusion in single-celled tubes. Dev. Cell 14:465-6. PubMed

Yap, A., Crampton, M.S., and Hardin, J. (2007). Making and breaking contacts: the cellular biology of cadherin regulation. Curr. Opin. Cell Biol. 19:508-514. PubMed

Walston, T. and Hardin, J. (2006). Wnt-dependent spindle polarization in the early C. elegans embryo. Sem. Cell Dev. Biol., 17, 204-213. PubMed

Hardin, J., and Walston, T. (2004). Models of morphogenesis: the mechanisms and mechanics of cell rearrangement. Curr Opin Genet Dev 14, 399-406. PubMed

Hardin, J., and Lockwood, C. (2004). Skin tight: cell adhesion in the epidermis of Caenorhabditis elegans. Curr Opin Cell Biol 16, 486-492. PubMed

Cox, E.A., Tuskey, C., and Hardin, J. (2004). Cell adhesion receptors in C. elegans. J Cell Sci 117, 1867-1870. PubMed

Cox, E.A., and Hardin, J. (2004). Sticky worms: adhesion complexes in C. elegans. J Cell Sci 117, 1885-1897. PubMed

Simske, J.S., and Hardin, J. (2001). Getting into shape: epidermal morphogenesis in Caenorhabditis elegans embryos. Bioessays 23, 12-23. PubMed

Hardin, J. (2000). Development. A degrading way to make an organ. Science 288, 2142-2143. PubMed

Hardin, J., Raich, W.B. and Simske, J.S. (2000) Morphogenesis at single-cell resolution: studying changes in the shape of the embryo in the tradition of Hörstadius. In: "Regulatory Processes in Development" (C.-O. Jacobson, L. Olson, eds) Wenner-Gren International Series, Vol. 76, pp.125-147. Portland Press, London.
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Research articles and reviews - Microscopy
Sims, P. A., and Hardin, J. D. (2007). Fluorescence-integrated transmission electron microscopy images: integrating fluorescence microscopy with transmission electron microscopy. Methods Mol Biol 369: 291-308. PubMed

Hardin, J. (2006). Confocal and Multi-Photon Imaging of Living Embryos. In Handbook of Biological Confocal Microscopy, 3e (J. Pawley, ed.). New York: Springer, pp. 746-768.

Sims, P., Albrecht, R., Pawley, J.B., Centonze, V., Deerink, T., and Hardin, J. (2006). When Light Microscope Resolution Is Not Enough: Correlational Light Microscope and Electron Microscope. In Handbook of Biological Confocal Microscopy, 3e (J. Pawley, ed.). New York: Springer, pp. 846-860.

Sims, P., Lockwood, C. and Hardin, J. (2005). Integrating light and TEM information with F-TEM images. Microscopy Today 13(5), 16-18. PDF of entire issue (33.5 Mb!)

Heid, P.J., and Hardin, J. (2000). Cell lineage analysis. Videomicroscopy techniques. Methods Mol Biol 135, 323-330.

Thomas, C., DeVries, P., Hardin, J., and White, J. (1996). Four-dimensional imaging: computer visualization of 3D movements in living specimens. Science 273, 603-607. PubMed
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Research articles - Sea urchins
Hardin, J. and Illingworth, C. (2006). A homologue of snail is expressed transiently in subsets of mesenchyme cells in the sea urchin embryo and is down-regulated in axis-deficient embryos. Dev. Dyn. 235, 3121-31. PubMed

Kimberly, E.L., and Hardin, J. (1998). Bottle cells are required for the initiation of primary invagination in the sea urchin embryo. Dev Biol 204, 235-250. PubMed

Hardin, J., and Armstrong, N. (1997). Short-range cell-cell signals control ectodermal patterning in the oral region of the sea urchin embryo. Dev Biol 182, 134-149. PubMed

Benink, H., Wray, G., and Hardin, J. (1997). Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. Development 124, 3461-3470. PubMed

Armstrong, N., Hardin, J., and McClay, D.R. (1993). Cell-cell interactions regulate skeleton formation in the sea urchin embryo. Development 119, 833-840. PubMed

Hardin, J., Coffman, J.A., Black, S.D., and McClay, D.R. (1992). Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2. Development 116, 671-685. PubMed
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Reviews - Sea urchins
Hardin, J. (1996). The cellular basis of sea urchin gastrulation. Curr Top Dev Biol 33, 159-262. PubMed

Hardin, J. (1995). Target recognition by mesenchyme cells in the sea urchin embryo. Amer. Zool. 35, 358-371.

Hardin, J. (1994). Local cell-cell interactions and the regulation of gastrulation. Sem. Dev. Biol. 5, 77-84.

McClay, D.R., Armstrong, N.A., and Hardin, J. (1992). Pattern formation during gastrulation in the sea urchin embryo. Dev Suppl, 33-41. PubMed

McClay, D.R., Morrill, J., and Hardin, J. (1991). Archenteron morphogenesis in the sea urchin. In "Cell-Cell Interactions in Early Development" (J. Gerhart, ed.), New York, Alan R. Liss, pp. 15-29.
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Jeff's earlier publications
Hardin, J. (1990). Context-sensitive cell behaviors during gastrulation. Sem. Dev. Biol. 1, 335-345.

Hardin, J., and McClay, D.R. (1990). Target recognition by the archenteron during sea urchin gastrulation. Dev Biol 142, 86-102. PubMed

Hardin, J. (1989). Local shifts in position and polarized motility drive cell rearrangement during sea urchin gastrulation. Dev Biol 136, 430-445. PubMed

Hardin, J., and Keller, R. (1988). The behaviour and function of bottle cells during gastrulation of Xenopus laevis. Development 103, 211-230. PubMed

Hardin, J. (1988). The role of secondary mesenchyme cells during sea urchin gastrulation studied by laser ablation. Development 103, 317-324. PubMed

Keller, R., and Hardin, J. (1987). Cell behaviour during active cell rearrangement: evidence and speculations. J Cell Sci Suppl 8, 369-393.

Hardin, J.D. (1987). Archenteron elongation in the sea urchin embryo is a microtubule-independent process. Dev Biol 121, 253-262. PubMed

Butler, E., Hardin, J., and Benson, S. (1987). The role of lysyl oxidase and collagen crosslinking during sea urchin development. Exp Cell Res 173, 174-182. PubMed

Stephens, L., Hardin, J., Keller, R., and Wilt, F. (1986). The effects of aphidicolin on morphogenesis and differentiation in the sea urchin embryo. Dev Biol 118, 64-69. PubMed

Hardin, J.D., and Cheng, L.Y. (1986). The mechanisms and mechanics of archenteron elongation during sea urchin gastrulation. Dev. Biol. 115 490-501. Abstract
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Teaching Publications & Books
Books
Becker, W., Kleinsmith, L., Hardin, J. , and Bertoni, G. (2008). The World of the Cell, 7th ed. San Francisco: Benjamin Cummings. Available in early 2008.

Becker, W., Kleinsmith, L., and Hardin, J. (2005). The World of the Cell, 6th ed. San Francisco: Benjamin Cummings. Amazon

Previous editions:
Becker, W., Kleinsmith, L., and Hardin, J. (2003). The World of the Cell, 5th ed. San Francisco: Benjamin Cummings.

Becker, W., Kleinsmith, L., and Hardin, J. (2000). The World of the Cell, 4th ed. San Francisco: Benjamin Cummings.

Articles
Hardin, J. (2008). The missing dimension in developmental biology education. CBE Life Sci Educ. 7:13-6. PubMed

Savage, M.P., Fallon, J.F., and Hardin, J. (2003). Gilbert’s seventh hits all the right notes: A synthesis for everyone. Dev. Dyn. 227, 615–616. Abstract

Savage, M.P., Fallon, J.F., and Hardin, J. (2003). Teaching the essential principles of development. Bioessays 25,301–302. Abstract
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