THE HARDIN LABMicroscopy: Reviews and articles
Protocols: Protocols
Sea urchins: Research or Reviews
Older work: Articles
Teaching: Articles and books
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Research articles - C. elegans
Le*, S., Yu*, M., Fu*, C., Heier, J.A., Martin, S., Hardin, J., and Yan, J. (2024). Single-molecule force spectroscopy reveals intra- and intermolecular interactions of C. elegans HMP-1 during mechanotransduction. Proc. Nat. Acad. Sci. USA 2024 Sep 10;121(37):e2400654121. (*= co-first authors) PubMed .
*Zhu, Y., *Tesone, Z., Tan, M., and Hardin, J. (2024). TIAM-1 regulates polarized protrusions during dorsal intercalation in the C. elegans embryo through both its GEF and N-terminal domains. J. Cell Sci. 137(5):jcs261509. (*co-first authors) PubMed
Martin, S.C.T., Qadota, H., Oberhauser, A.F., Hardin, J., and Benian, G.M. (2023). FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans. Mol. Biol. Cell 34:ar86, 1–13, August 1, 2023. PubMed
Serre, J.M. Mark M. Slabodnick, M.S., Goldstein, B. and Hardin, J. (2023). SRGP-1/srGAP and AFD-1/Afadin stabilize HMP-1/α-Catenin at rosettes to seal internalization sites following gastrulation in C. elegans. PLoS Genet. 2023 Mar 3;19(3):e1010507. doi: 10.1371/journal.pgen.1010507. PubMed
Lynch, A.M.*, Zhu, Y.*, Lucas, B.G., Winkelman, J.D., Bai, K., Martin, S.C.T. , Samuel Block, S., Slabodnick, M.S., Audhya, A., Goldstein, B., Pettitt, J., Gardel, M.L., and Hardin, J.(2022). TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Curr. Biol 32, 5189–5199 (*= co-first authors). PubMed
Serre, J.M., Lucas, B., Martin, S.C.M. , Heier, J.A., Xiangqiang Shao, X., and Jeff Hardin, J. (2022). C. elegans srGAP is an α-catenin M domain-binding protein that strengthens cadherin-dependent adhesion during morphogenesis. Development 149 (18): dev200775. . PubMed
Serre, JM; Hardin, J (2022). The Lamellipodin homologue MIG-10 is not essential for dorsal intercalation in the embryonic epidermis of the C. elegans embryo. microPublication Biology. https://doi.org/10.17912/micropub.biology.000522 PubMed
Shao, X., Lucas, B.G., Strauch, J. and Hardin, J. (2019). The adhesion modulation domain of C. elegans α-catenin regulates actin binding during morphogenesis. Mol. Biol. Cell 30:2115-2123. PubMed
Loveless, T., Qadota, H., Benian, GM., and Hardin, J. (2017). C. elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes. Mol. Bio. Cell, 28:3621-3633. PubMed
Shao, X. Kang, H., Loveless, T., Lee, G.R., , Seok, C., Weis, W.I., and Choi, H.-J., and Hardin, J. (2017). Cell–cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin•β-catenin–binding interface. J. Biol. Chem. 292,16477–16490. PubMed
Kang, H., Bang, I., Jin, K.S., Lee, B., Lee, J., Shao, X., Heier, J.A., Kwiatkowski, A.V., Nelson, W.J., Hardin, J., Weis, W., and Choi, H.-J. (2017). Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and actin. J. Biol. Chem. 29, 7077-7086. PubMed
Walck-Shannon, E., Lucas, B., Chin-Sang, I., Reiner, D., Kumfer, K., Cochran, H., Bothfeld, W., and Hardin, J. (2016). CDC-42 orients cell migration during epithelial intercalation in the Caenorhabditis elegans epidermis. PLOS Genetics 12(11): e1006415. PubMed
Walck-Shannon, E., Reiner, D., and Hardin, J. (2015). Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans. Development 142:3549-3560. PubMed
Choi, H.-J.*+, Loveless, T.*, Lynch, A.M., Bang, I., Hardin, J+, and Weis, W.I.+ (2015). A conserved phosphorylation switch controls the interaction between cadherin and β-catenin In vitro and In vivo. Developmental Cell 33, 82–93. [*Co-first authors; +Corresponding authors] PubMed
Callaci, S., Morrison, K., Shao, X., Schuh, A.L. Wang, Y., Yates III, J.R., Hardin, J., and Audhya, A. (2015). Phosphoregulation of the C. elegans cadherin-catenin complex. Biochemistry 472:339-52. PubMed
Maiden, S.L., Harrison, N., Keegan, J., Cain, B., Lynch, A.M., Pettitt, J., and Hardin, J. (2013). Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin. J. Biol. Chem. 288:5694-706. PubMed
Lynch, A.M., Grana, T., Cox-Paulson, E., Couthier, A., Cameron, M., Chin-Sang, I., Pettitt, J., and Hardin, J. (2012). A genome-wide functional screen identifies MAGI-1 as an L1CAM-dependent stabilizer of apical junctions in C. elegans. Curr. Biol. 22, 1891–1899. PubMed
Cox-Paulson, E., Walck-Shannon, E., Lynch, A., Yamashiro, S., Zaidel-Bar, R., Celeste C. Eno, C., Ono, S., and Hardin, J. (2012). Tropomodulin protects α-catenin-dependent junctional actin networks under stress during epithelial morphogenesis. Curr. Biol. 22:1500-1505. PubMed
Ikegami, R., Simokat, K., Zheng, H., Dixon, L., Garriga, G., Hardin, J. and Culotti, J. (2012). Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans. Curr. Biol. 22:1–11. PubMed
Neukomm, L.J., Frei, A.P., Cabello, J., Kinchen, J.M., Zaidel-Bar, R., Ma, Z., Haney, L.B., Hardin, J., Ravichandran, K.S., Moreno, S., and Hengartner, M.O. (2011). Loss of the RhoGAP SRGP1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nature Cell Biol. 13:79-86. PubMed
Zaidel-Bar, R., Joyce, M.J., Lynch, A.M., Witte, K., Audhya, A., and Hardin, J. (2010). The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J. Cell Biol. 191, 761-9. PubMed JCB In This Issue
Kwiatkowski, A.V., Maiden, S.L., Pokutta, S., Choi, H.-J., Benjamin, J.M., Lynch, A.M., Nelson, W.J., Weis, W.I., and Hardin, J. (2010). In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. Proc Natl Acad Sci U S A. 107:14591-14596. PubMed
Grana, T.M., Cox, E.A., Lynch, A.M., and Hardin, J. (2010). SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation. Dev. Biol. 344:731–744. PubMed
Giuliani, C., Troglio, F., T., Zucconi, A., Bai, Z., Patel, F.B., Zucconi, A., Malabarba, M.G., Disanza, A., Stradal, T., Cassata, G., Confalonieri, S., Hardin, J., Soto, M., Grant, B., and Scita, G. (2009). Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during C. elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genetics 5(10): e1000675. PubMed
King, R.S., Maiden, S.L., Hawkins, N.C., Kidd, A.R., Kimble, J., Hardin, J., and Walston, T.D.(2009). POP-1 asymmetry and morphogenesis defects in dsh-2 mutant embryos can be rescued by either the DIX or DEP domain of DSH-2. Dev. Biol. 328: 234-44. PubMed
Hingwing, K., Lee, S., Nykilchuk, L., Walston, T., Hardin, J., and Hawkins, N. (2009). CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a β-catenin independent Wnt pathway. Dev Biol. 328: 245–56. PubMed
Yamashiro, S., Cox, E.A., Ballie, D.L., Hardin, J. and Ono, S. (2008). Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1, and profilin in C. elegans. J. Cell Sci. 121:3867-77. PubMed
Ding, M., King, R.S., Berry, E.C., Wang, Y., Hardin, J., and Chisholm, A.D. (2008). The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PLoS ONE 3:e3346. PubMed
Lockwood, C., Zaidel-Bar, R., and Hardin, J. (2008). The C. elegans Zonula Occludens ortholog ZOO-1 cooperates with the cadherin-catenin complex to recruit actin during epidermal morphogenesis. Curr. Biol. 18:1333-7. PubMed
Lockwood, C., Lynch, A., and Hardin, J. (2008). Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413 dependent apical focusing. J. Cell Sci. 121: 1477-1487. PubMed
Hardin, J., King, R., Thomas-Virnig, C., and Raich, W.B. (2008). Zygotic loss of ZEN-4/MKLP1 results in disruption of epidermal morphogenesis in the C. elegans embryo. Dev. Dyn. 237:830-6. PubMed
Stevenson, T.O., Mercer, K., Cox, E.A., Szewczyk, N.J., Conley, C.A., Hardin, J.D., and Benian, G.M. (2007). unc-94 encodes a tropomodulin in C. elegans. J. Mol. Biol. 374, 936-50. PubMed
Sheffield, M.S., Loveless, T., Hardin, J., and Pettitt, J. (2007). C. elegans Enabled exhibits novel interactions with N-WASP, Abl, and cell-cell junctions. Curr. Biol. 17, 1791-1796. PubMed
Batchelder EL, Thomas-Virnig CL, Hardin JD, White JG. (2007). Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo. FEBS Letters 581:4337-41. PubMed
Qadota H, Inoue M, Hikita T, Köppen M, Hardin JD, Amano M, Moerman DG, Kaibuchi K. (2007). Establishment of a tissue-specific RNAi system in C. elegans. Gene 400:166-73. PubMed
Phillips, B. T., Kidd, A. R., 3rd, King, R., Hardin, J. and Kimble, J. (2007). Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 104: 3231-6. PubMed
Lee, J.-Y., Marston, D.J., Halberstadt, A., Walston, T., Hardin, J. and B. Goldstein, B. (2006). Wnt/Frizzled signaling regulates C. elegans gastrulation through activation of actomyosin contractility. Curr. Biol. 16:1986-97. PubMed
Walston, T., Guo, C., Proenca, R., Wu, M., Herman, M., Hardin, J., and Hedgecock, E. (2006). mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev. Bio. 298, 485-497. PubMed
Walston, T., Tuskey, C., Edgar, L., Hawkins, N., Ellis, G., Bowerman, B., Wood, W., and Hardin, J. (2004). Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev. Cell 7, 831-841. PubMed
Thomas-Virnig, C.L., Simske, J.S., Sims, P.A., and Hardin, J. (2004). The inositol 1, 4, 5-trisphosphate receptor regulates epidermal cell migration in Caenorhabditis elegans. Curr. Biol. 14,1882-7. PubMed
Pettitt, J., Cox, E.A., Broadbent, I.D., Flett, A., and Hardin, J. (2003). The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J Cell Biol 162, 15-22. PubMed
Simske, J.S., Köppen, M., Sims, P., Hodgkin, J., Yonkof, A., and Hardin, J. (2003). The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Nat Cell Biol 5, 619-625. PubMed
Köppen, M., Simske, J.S., Sims, P.A., Firestein, B.L., Hall, D.H., Radice, A.D., Rongo, C., and Hardin, J.D. (2001). Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol 3, 983-991. PubMed
Heid, P.J., Raich, W.B., Smith, R., Mohler, W.A., Simokat, K., Gendreau, S.B., Rothman, J.H., and Hardin, J. (2001). The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans. Dev Biol 236, 165-180. PubMed
Raich, W.B., Agbunag, C., and Hardin, J. (1999). Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming. Curr Biol 9, 1139-1146. PubMed
Williams-Masson, E.M., Heid, P.J., Lavin, C.A., and Hardin, J. (1998). The cellular mechanism of epithelial rearrangement during morphogenesis of the Caenorhabditis elegans dorsal hypodermis. Dev Biol 204, 263-276. PubMed
Raich, W.B., Moran, A.N., Rothman, J.H., and Hardin, J. (1998). Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Mol Biol Cell 9, 2037-2049. PubMed
Mohler, W.A., Simske, J.S., Williams-Masson, E.M., Hardin, J.D., and White, J.G. (1998). Dynamics and ultrastructure of developmental cell fusions in the Caenorhabditis elegans hypodermis. Curr Biol 8, 1087-1090. PubMed
George, S.E., Simokat, K., Hardin, J., and Chisholm, A.D. (1998). The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell 92, 633-643. PubMed
Costa, M., Raich, W., Agbunag, C., Leung, B., Hardin, J., and Priess, J.R. (1998). A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol 141, 297-308. PubMed
Williams-Masson, E.M., Malik, A.N., and Hardin, J. (1997). An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis. Development 124, 2889-2901. PubMed
Draper, B.W., Mello, C.C., Bowerman, B., Hardin, J., and Priess, J.R. (1996). MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell 87, 205-216. PubMed
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Reviews - C. elegans and adhesion
Lucas, B. and Hardin, J. (2017). Mind the (sr)GAP – roles of Slit/Robo GAPs in neurons, brains, and beyond. J. Cell Sci. 130: 3965-3974. PubMed
Walck-Shannon, E. and Hardin, J. (2016). Another morphogenetic movement on the map: Charting dorsal intercalation in C. elegans.. Worm 5:2, e1176664. PubMed
Hardin, J. (2016). Regulating cell-cell junctions from A to Z. J. Cell Biol. 213, 151–153. PubMed
Hardin, J. (2015). Getting to the core of of the cadherin complex in C. elegans. F1000Research 2015, 4(F1000 Faculty Rev):1473 (doi: 10.12688/f1000research.6866.1) PubMed
Walck-Shannon, E. and Hardin, J. (2014). Cell intercalation from top to bottom. Nature Rev. Mol. Cell. Bio 15:34-48. Pubmed
Hardin, J., Lynch, A., Loveless, T., and Pettitt, J. (2013). Cadherins and their partners in the nematode worm Caenorhabditis elegans. In "The Molecular Biology of Cadherins" (ed. F. van Roy). Prog Mol Biol Transl Sci.116:239-62. PubMed
Loveless, T. and Hardin, J. (2012). Cadherin complexity: recent insights into cadherin superfamily function in C. elegans. Curr. Opin. Cell Biol. 24:695-701. PubMed
Hardin, J. (2012). An MBoC Favorite: "Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4". Mol. Biol. Cell 23:3025. PubMed
Maiden, S.L. and Hardin, J. (2011). The secret life of α-catenin: moonlighting during morphogenesis. J. Cell Biol. 195:543–552. PubMed
Schramp, M. and Hardin, J. (2011). Basement remodeling: making way for cellular invaders. Curr. Biol. 21:R585-587. PubMed
Simske, J.S. and Hardin, J. (2011). Claudins in C. elegans. Methods Mol. Biol. 762:147-69. PubMed Draft proof:
Hardin, J. (2011). Mechanotransduction: Getting morphogenesis down Pat. Curr. Biol. 21:R309-11. PubMed
Lynch, A.M. and J. Hardin. (2009). The assembly of epithelial junctions in C. elegans. Frontiers Biosci. 14:1414-1432. PubMed
Hardin, J., and King, R. (2008). The long and the short of Wnt signaling in C. elegans. Curr. Opin. Genetics & Devel. 18:362-7. PubMed
Hardin, J. (2008). Preview: To thine own self be true: Self-fusion in single-celled tubes. Dev. Cell 14:465-6. PubMed
Yap, A., Crampton, M.S., and Hardin, J. (2007). Making and breaking contacts: the cellular biology of cadherin regulation. Curr. Opin. Cell Biol. 19:508-514. PubMed
Walston, T. and Hardin, J. (2006). Wnt-dependent spindle polarization in the early C. elegans embryo. Sem. Cell Dev. Biol. 17, 204-213. PubMed
Chisholm, A. and Hardin, J. (2005). Epidermal morphogenesis. In WormBook, ed. The C. elegans Research Community, http://www.wormbook.org PubMed Wormbook (html)
Hardin, J., and Walston, T. (2004). Models of morphogenesis: the mechanisms and mechanics of cell rearrangement. Curr Opin Genet Dev 14, 399-406. PubMed
Hardin, J., and Lockwood, C. (2004). Skin tight: cell adhesion in the epidermis of Caenorhabditis elegans. Curr Opin Cell Biol 16, 486-492. PubMed
Cox, E.A., Tuskey, C., and Hardin, J. (2004). Cell adhesion receptors in C. elegans. J Cell Sci 117, 1867-1870. PubMed
Cox, E.A., and Hardin, J. (2004). Sticky worms: adhesion complexes in C. elegans. J Cell Sci 117, 1885-1897. PubMed
Simske, J.S., and Hardin, J. (2001). Getting into shape: epidermal morphogenesis in Caenorhabditis elegans embryos. Bioessays 23, 12-23. PubMed
Hardin, J. (2000). Development. A degrading way to make an organ. Science 288, 2142-2143. PubMed
Hardin, J., Raich, W.B. and Simske, J.S. (2000) Morphogenesis at single-cell resolution: studying changes in the shape of the embryo in the tradition of Hörstadius. In: "Regulatory Processes in Development" (C.-O. Jacobson, L. Olson, eds) Wenner-Gren International Series, Vol. 76, pp.125-147. Portland Press, London.
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Research articles and reviews - Microscopy
Hardin, J., Serre, J., King, R., Walck-Shannon, E., and Reiner, D. (2022). Imaging epidermal cell rearrangement in the C. elegans embryo. Methods Mol Biol 2438:345-376. PubMed
Hardin, J. (2011). Imaging embryonic morphogenesis in C. elegans. In: Joel H. Rothman and Andrew Singson, editors: Methods In Cell Biology, Vol 106, Oxford: Academic Press; 2011, p. 377-412. PubMed
Walston, T. and Hardin, J. (2011). Visualizing cell contacts and cell polarity in Caehorhabditis elegans embryos. In "Imaging in Developmental Biology: A Laboratory Manual" (Sharpe, J., Wong, R.O., eds). Cold Spring Harbor: Cold Spring Harbor Press, pp. 229-244.
Sims, P. A., and Hardin, J. D. (2007). Fluorescence-integrated transmission electron microscopy images: integrating fluorescence microscopy with transmission electron microscopy. Methods Mol Biol 369: 291-308. PubMed
Hardin, J. (2006). Confocal and Multi-Photon Imaging of Living Embryos. In Handbook of Biological Confocal Microscopy, 3e (J. Pawley, ed.). New York: Springer, pp. 746-768.
Sims, P., Albrecht, R., Pawley, J.B., Centonze, V., Deerink, T., and Hardin, J. (2006). When Light Microscope Resolution Is Not Enough: Correlational Light Microscope and Electron Microscope. In Handbook of Biological Confocal Microscopy, 3e (J. Pawley, ed.). New York: Springer, pp. 846-860.
Sims, P., Lockwood, C. and Hardin, J. (2005). Integrating light and TEM information with F-TEM images. Microscopy Today 13(5), 16-18.
Heid, P.J., and Hardin, J. (2000). Cell lineage analysis. Videomicroscopy techniques. Methods Mol Biol 135, 323-330. PubMed
Thomas, C., DeVries, P., Hardin, J., and White, J. (1996). Four-dimensional imaging: computer visualization of 3D movements in living specimens. Science 273, 603-607. PubMed
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Protocols
Walston, T. and Hardin J. (2010). Laser Killing of Blastomeres in Caenorhabditis elegans. Cold Spring Harb. Protoc. doi: 10.1101/pdb.prot5543. PubMed
Walston, T. and Hardin, J. (2010). Acquisition of 4D DIC microscopic data to determine cell contacts in Caenorhabditis elegans embryos. Cold Spring Harb. Protoc. doi:10.1101/pdb.prot5541 PubMed
Walston, T. and Hardin J. (2010). An agar mount for observation of Caenorhabditis elegans embryos. Cold Spring Harb. Protoc. doi:10.1101/pdb.prot5540 PubMed
Walston, T. and Hardin J. (2010). Analysis of 4D DIC microscopic data to determine cell contacts in Caenorhabditis elegans embryos. Cold Spring Harb. Protoc. doi:10.1101/pdb.prot5542 PubMed
Research articles - Sea urchins
Hardin, J. and Weliky, M. (2019). Cell rearrangement induced by filopodial tension accounts for the late phase of convergent extension in the sea urchin archenteron. Mol. Biol. Cell 30:1911-1919. PubMed
Hardin, J. and Illingworth, C. (2006). A homologue of snail is expressed transiently in subsets of mesenchyme cells in the sea urchin embryo and is down-regulated in axis-deficient embryos. Dev. Dyn. 235, 3121-31. PubMed
Weng, W., Cheetham , J., Hardin, J., and Venuti, J.M. (2000) A twist in sea urchin gastrulation and mesoderm specification. In: "Regulatory Processes in Development" (C.-O. Jacobson, L. Olson, eds) Wenner-Gren International Series, Vol. 76, pp. 153-158. Portland Press, London.
Kimberly, E.L., and Hardin, J. (1998). Bottle cells are required for the initiation of primary invagination in the sea urchin embryo. Dev Biol 204, 235-250. PubMed
Hardin, J., and Armstrong, N. (1997). Short-range cell-cell signals control ectodermal patterning in the oral region of the sea urchin embryo. Dev Biol 182, 134-149. PubMed
Benink, H., Wray, G., and Hardin, J. (1997). Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. Development 124, 3461-3470. PubMed
Armstrong, N., Hardin, J., and McClay, D.R. (1993). Cell-cell interactions regulate skeleton formation in the sea urchin embryo. Development 119, 833-840. PubMed
Hardin, J., Coffman, J.A., Black, S.D., and McClay, D.R. (1992). Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2. Development 116, 671-685. PubMed
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Reviews - Sea urchins
Hardin, J. (1996). The cellular basis of sea urchin gastrulation. Curr Top Dev Biol 33, 159-262. PubMed
Hardin, J. (1995). Target recognition by mesenchyme cells in the sea urchin embryo. Amer. Zool. 35, 358-371.
Hardin, J. (1994). Local cell-cell interactions and the regulation of gastrulation. Sem. Dev. Biol. 5, 77-84.
Hardin, J. (1994). The sea urchin embryo. In "Embryos: Color Atlas of Development" (J. Bard, ed.), pp. 37-53. London, Wolfe Publishing.
McClay, D.R., Armstrong, N.A., and Hardin, J. (1992). Pattern formation during gastrulation in the sea urchin embryo. Developmernt Suppl, 33-41. PubMed
McClay, D.R., Morrill, J., and Hardin, J. (1991). Archenteron morphogenesis in the sea urchin. In "Cell-Cell Interactions in Early Development" (J. Gerhart, ed.), New York, Alan R. Liss, pp. 15-29.
McClay, D.R., Alliegro, M.C., and Hardin, J.D. (1989). Cell interactions as epigenetic signals in morphogenesis of the sea urchin embryo. In "The Cellular and Molecular Biology of Pattern Formation" (ed. D. Stocum). Oxford, Oxford University Press, pp. 70-87.
McClay, D.R., Coffman, J.C., and Hardin, J.D. (1989). Epigenetic signals at gastrulation in the sea urchin. U.C.L.A. Symp. Mol. Cell. Biol, New Series, Vol. 25 (eds. E. Davidson, J. Ruderman, and J. Posakony). New York, Alan R. Liss, pp. 251-255.
topJeff's earlier publications
Hardin, J. (1990). Context-sensitive cell behaviors during gastrulation. Sem. Dev. Biol. 1, 335-345.
Hardin, J., and McClay, D.R. (1990). Target recognition by the archenteron during sea urchin gastrulation. Dev Biol 142, 86-102. PubMed
Hardin, J. (1989). Local shifts in position and polarized motility drive cell rearrangement during sea urchin gastrulation. Dev Biol 136, 430-445. PubMed
Hardin, J., and Keller, R. (1988). The behaviour and function of bottle cells during gastrulation of Xenopus laevis. Development 103, 211-230. PubMed
Hardin, J. (1988). The role of secondary mesenchyme cells during sea urchin gastrulation studied by laser ablation. Development 103, 317-324. PubMed
Keller, R., and Hardin, J. (1987). Cell behaviour during active cell rearrangement: evidence and speculations. J Cell Sci Suppl 8, 369-393.
Hardin, J.D. (1987). Archenteron elongation in the sea urchin embryo is a microtubule-independent process. Dev Biol 121, 253-262. PubMed
Butler, E., Hardin, J., and Benson, S. (1987). The role of lysyl oxidase and collagen crosslinking during sea urchin development. Exp Cell Res 173, 174-182. PubMed
Stephens, L., Hardin, J., Keller, R., and Wilt, F. (1986). The effects of aphidicolin on morphogenesis and differentiation in the sea urchin embryo. Dev Biol 118, 64-69. PubMed
Hardin, J.D., and Cheng, L.Y. (1986). The mechanisms and mechanics of archenteron elongation during sea urchin gastrulation. Dev. Biol. 115 490-501. Abstract
topTeaching Publications & Books
Books
Hardin, J.,, and Lodolce, J (2021). The World of the Cell, 10th ed. San Francisco: Pearson., in press.
Hardin, J., and Kleinsmith, L. (2016). The World of the Cell, 9th ed. San Francisco: Pearson. Amazon.
Previous editions:
Hardin, J., Bertoni, G., and Kleinsmith, L. (2011). The World of the Cell, 8th ed. San Francisco: Pearson. Amazon
Becker, W., Kleinsmith, L., Hardin, J. , and Bertoni, G. (2008). The World of the Cell, 7th ed. San Francisco: Benjamin Cummings. Amazon
Becker, W., Kleinsmith, L., and Hardin, J. (2005). The World of the Cell, 6th ed. San Francisco: Benjamin Cummings.
Becker, W., Kleinsmith, L., and Hardin, J. (2003). The World of the Cell, 5th ed. San Francisco: Benjamin Cummings.
Becker, W., Kleinsmith, L., and Hardin, J. (2000). The World of the Cell, 4th ed. San Francisco: Benjamin Cummings.
Articles
Hardin, J. (2008). The missing dimension in developmental biology education. CBE Life Sci Educ. 7:13-6. PubMed
Savage, M.P., Fallon, J.F., and Hardin, J. (2003). Gilbert’s seventh hits all the right notes: A synthesis for everyone. Dev. Dyn. 227, 615–616. Abstract
Savage, M.P., Fallon, J.F., and Hardin, J. (2003). Teaching the essential principles of development. Bioessays 25,301–302. Abstract
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